Gene information
Official symbol SOCS3
Official full name suppressor of cytokine signaling 3
Gene type protein-coding gene
Chromosome17q25.3
Alias symbolSSI-3; CIS3; SOCS-3; Cish3
Gene familySH2 domain containing; Suppressors of cytokine signaling
Resources
Entrez Gene 9021
HGNC HGNC:19391
Ensembl ENSG00000184557
Vega OTTHUMG00000177513
UCSC uc002jvl.4
GO terms: 51 records
GO Description Category LogP Number of genes Detail
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001701 in utero embryonic development GO Biological Processes -8.76987260 44 More
GO:0001763 morphogenesis of a branching structure GO Biological Processes -11.2402819 31 More
GO:0001890 placenta development GO Biological Processes -8.66149584 25 More
GO:0001892 embryonic placenta development GO Biological Processes -3.02613520 11 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0006644 phospholipid metabolic process GO Biological Processes -2.96272379 13 More
GO:0007259 receptor signaling pathway via JAK-STAT GO Biological Processes -5.73581155 7 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0019207 kinase regulator activity GO Molecular Functions -2.87704457 10 More
GO:0019210 kinase inhibitor activity GO Molecular Functions -2.42307363 9 More
GO:0019887 protein kinase regulator activity GO Molecular Functions -2.69690139 9 More
GO:0019898 extrinsic component of membrane GO Cellular Components -2.13392265 23 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.4049069 20 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0046425 regulation of receptor signaling pathway via JAK-STAT GO Biological Processes -10.5317026 20 More
GO:0046486 glycerolipid metabolic process GO Biological Processes -5.86759713 18 More
GO:0046626 regulation of insulin receptor signaling pathway GO Biological Processes -7.79385832 16 More
GO:0046627 negative regulation of insulin receptor signaling pathway GO Biological Processes -4.76875730 9 More
GO:0048568 embryonic organ development GO Biological Processes -17.1204114 64 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0060669 embryonic placenta morphogenesis GO Biological Processes -2.31427790 5 More
GO:0060711 labyrinthine layer development GO Biological Processes -3.15848951 8 More
GO:0061138 morphogenesis of a branching epithelium GO Biological Processes -11.1441029 30 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0090407 organophosphate biosynthetic process GO Biological Processes -3.52771570 18 More
GO:0097696 receptor signaling pathway via STAT GO Biological Processes -5.66899995 7 More
GO:1900076 regulation of cellular response to insulin stimulus GO Biological Processes -8.81141992 11 More
GO:1900077 negative regulation of cellular response to insulin stimulus GO Biological Processes -5.46127869 10 More
GO:1904892 regulation of receptor signaling pathway via STAT GO Biological Processes -12.9980471 24 More
GO:1990823 response to leukemia inhibitory factor GO Biological Processes -3.54378087 13 More
GO:1990830 cellular response to leukemia inhibitory factor GO Biological Processes -3.58748665 13 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa04630 JAK-STAT signaling pathway KEGG Pathway -14.4088859 21 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa04917 Prolactin signaling pathway KEGG Pathway -3.17844000 10 More
hsa04920 Adipocytokine signaling pathway KEGG Pathway -10.4150431 19 More
hsa04930 Type II diabetes mellitus KEGG Pathway -3.96920305 9 More
hsa04931 Insulin resistance KEGG Pathway -8.40376708 21 More
hsa04935 Growth hormone synthesis, secretion and action KEGG Pathway -2.82078524 13 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
SOCS3 transcriptomics poor predictor acute myocardial infarction[diagnosis] acute myocardial infarction Zhuo LA et al. J Biol Chem. 2019
SOCS3 transcriptomics acute myocardial infarction[diagnosis] acute myocardial infarction Meng HY et al. Genet Test Mol Biomarkers. 2020
suppressor of cytokine signaling 3 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Meng HY et al. Genet Test Mol Biomarkers. 2020
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